Cancer cells that slip free of chemotherapy’s deadly embrace sometimes manage to do so because they possess slippery DNA repair proteins. Among the slipperiest are translesion synthesis (TLS) ...
Translesion synthesis genes POLI and REV1 in breast tumors and response to neoadjuvant chemotherapy.
Correlation between HER2 amplification level and response to neoadjuvant treatment with trastuzumab and chemotherapy in HER2 positive breast cancer. ER+ breast cancer response to NACT response and ...
Many chemotherapy drugs kill cancer cells by severely damaging their DNA. However, some tumors can withstand this damage by relying on a DNA repair pathway that not only allows them to survive, but ...
Researchers have discovered a potential drug compound that can block a mutagenic DNA repair pathway that helps cancer cells survive chemotherapy. When they treated mice with this compound along with ...
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