Cells organize their molecules into distinct functional areas. While textbooks usually refer to membrane-bound organelles ...

These include stress granules and proteasome storage granules (PSGs). In the past, these membraneless organelles were only visible as “droplets” using a fluorescence microscope. Now, researchers from ...

QLi5 Therapeutics GmbH (QLi5), a spin-off from the Max Planck Institute for Biochemistry, has successfully completed a ...

Booster Therapeutics (Germany) focuses on developing small-molecule proteasome activators for neurodegenerative disease using ...

he ubiquitin‒proteasome system (UPS) and autophagy are protein degradation pathways essential for maintaining protein balance and regulation, or proteostasis (left panel). When proteasome activity ...

Proteasome inhibitors have brought major advances in the treatment of multiple myeloma (MM), but eventual drug resistance remains a serious hurdle. Drug resistance continues to be a major problem in ...

Tyrosine kinase inhibitors to regulate the expression level of ABC transporters related to multidrug resistance. An examination of the BET bromodomain inhibitor JQ1 in comparison with histone ...

Genes & Diseases is a journal for molecular and translational medicine. The journal primarily focuses on publishing investigations on the molecular bases and experimental therapeutics of human ...

Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...