G-protein coupled receptors (GPCRs) are seven-pass transmembrane proteins involved in numerous signaling pathways. Upon extracellular ligand binding and activation, members of this superfamily mediate ...

Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...

Trace amine-associated receptor 1 (TAAR1) is a member of the G protein-coupled receptor (GPCR) TAAR family, which has been shown to be enriched in the central nervous system and periphery. TAAR1 can ...

Researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons. University of Michigan researchers have developed a new tool to better ...

University of Michigan researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons. These chemicals are among a wide variety of signals ...