ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know about the Week 16 game.

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how to watch live and streaming.

The San Francisco 49ers hit the road in Week 16 for a “Monday Night Football” showdown with veteran gunslinger Philip Rivers and the Indianapolis Colts.

The Colts host the 49ers on tonight’s edition of Monday Night Football. The 49ers/Colts game begins at 8:15 p.m. ET on ESPN. Nope. But the Manning boys will return to ESPN2 for the Monday night wild-card matchup on January 12.

To his credit, Rivers held up his end of the bargain, keeping the Colts in the game late vs. the Seahawks before losing on a late field goal (and a Rivers INT). Rivers played relatively well in his first game action since 2020,

No. 6 Ole Miss (12-1, 7-1 SEC) took the field in front of a sold out crowd at Vaught-Hemingway Stadium with the Rebels dominating in their College Football Play

It's the San Francisco vs Indianapolis Colts to close out NFL Week 16 on Monday Night Football. Here's the start time, TV channel, streaming info.

It's the San Francisco 49ers vs Indianapolis Colts on Monday Night Football in Week 16 of the 2025 NFL season. Here's how to watch, including time, TV channel and streaming info.

The San Francisco 49ers, on a four-game winning streak, try to stay hot Monday night against an Indianapolis Colts team on a four-game losing streak.